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Updated: Jun 1, 2026

Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid
Published on: November 15, 2017
(E)-N'-(2,4-Dichloro-benzyl-idene)-3-nitro-benzohydrazide
1Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Department of Chemistry, Yancheng Teachers University, Yancheng 224002, People's Republic of China.
Researchers synthesized a novel compound, C(14)H(9)Cl(2)N(3)O(3), via a chemical reaction. Crystal analysis revealed specific molecular configurations and intermolecular hydrogen bonding, forming chain structures.
Area of Science:
- Organic Chemistry
- Crystallography
- Molecular Structure
Background:
- Hydrazone derivatives are important in medicinal chemistry.
- Understanding molecular structure and bonding is crucial for material science.
Purpose of the Study:
- To synthesize and characterize a novel hydrazone compound.
- To investigate the molecular geometry and crystal packing.
Main Methods:
- Chemical synthesis involving 3-nitro-benzohydrazide and 2,4-dichloro-benzaldehyde.
- X-ray crystallography to determine molecular configuration and crystal structure.
Main Results:
- The compound C(14)H(9)Cl(2)N(3)O(3) was successfully synthesized.
- The molecule exhibits an E configuration around the C=N bond.
- Intermolecular N-H⋯O hydrogen bonds form chains along the c axis in the crystal structure.
Conclusions:
- The study reports the synthesis and structural elucidation of a new dichlorinated nitro-hydrazone.
- The crystal structure reveals specific intermolecular interactions dictating solid-state arrangement.
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