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Chromosome 13 poly(ADP-ribose) polymerase polymorphisms and lung cancer risk
E Bowman1, P Shields, N Caporaso
1NCI,HUMAN CARCINOGENESIS LAB,DIV BASIC SCI,NIH,BETHESDA,MD 20892. NCI,GENET EPIDEMIOL BRANCH,DIV EPIDEMIOL & GENET,NIH,BETHESDA,MD 20892. UNIV MARYLAND,DEPT PATHOL,BALTIMORE,MD 21201.
This study examined the poly(ADP-ribose) polymerase (PADPRP) pseudogene polymorphism in relation to lung cancer risk. The findings suggest this specific genetic marker on chromosome 13 is not a significant risk factor for lung cancer.
Area of Science:
- Genetics
- Oncology
- Population Studies
Background:
- A 193 base pair repeat polymorphism in the human poly(ADP-ribose) polymerase (PADPRP) pseudogene on chromosome 13 has been previously linked to various cancers.
- The PADPRP pseudogene's role in cancer etiology requires further investigation.
Purpose of the Study:
- To investigate the frequency of the PADPRP genetic polymorphism in a hospital-based case-control study of lung cancer.
- To determine if the PADPRP pseudogene polymorphism is a risk factor for lung cancer in different ethnic groups.
Main Methods:
- A case-control study was conducted with 54 lung cancer cases and 47 controls.
- Allelic frequencies of the PADPRP polymorphism were analyzed and compared between Caucasian and African American participants.
- Statistical analysis included calculating odds ratios and assessing Hardy-Weinberg equilibrium.
Main Results:
- A statistically significant difference in allelic frequency of the PADPRP polymorphism was observed between Caucasians and African Americans (p<0.001).
- For African Americans, the odds ratio for lung cancer associated with the 'B' allele was 2.38, while for Caucasians it was 0.44.
- Hardy-Weinberg equilibrium was not met for African Americans, but was observed in Caucasians.
Conclusions:
- Despite observed ethnic differences in allelic frequencies and a non-significant odds ratio for African Americans, this study does not support the PADPRP pseudogene polymorphism on chromosome 13 as a risk factor for lung cancer.
- The study highlights the importance of considering population-specific genetic variations in cancer research.
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