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Updated: Jun 1, 2026

Differentiation of Mouse Breast Epithelial HC11 and EpH4 Cells
Published on: February 27, 2020
The expression of E-cadherin as a prognostic factor in breast cancer
F Kawahara1, M Noguchi, R Yagasaki
1KANAZAWA UNIV HOSP,SCH MED,OPERAT CTR,KANAZAWA,ISHIKAWA 920,JAPAN. KANAZAWA UNIV HOSP,SCH MED,DEPT SURG 2,KANAZAWA,ISHIKAWA 920,JAPAN.
Abstract:
We examined the clinical significance of E-cadherin expression in 98 patients with breast cancer. E-cadherin expression significantly correlated with histologic grade (p=0.0323) and tended to correlate with the absence of axillary lymph node metastases (p=0.0646). The expression of E-cadherin was associated significantly with the recurrence rate (p=0.0334) and marginally associated with disease-free (p=0.0597) but not overall survival, in univariate analysis. The association between E-cadherin expression and disease-free survival was lost in multivariate analysis. The prognostic value of E-cadherin expression in breast cancer appears to be limited. A larger, prospective study with long-term follow-up is needed.
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