Related Experiment Video
Updated: Jun 1, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
Tumor proliferative compartment in non-Hodgkin's lymphoma
R Radhakrishnan1, V Gangadharan, M Nair
1REG CANC CTR,DIV LAB MED,THIRUVANANTHAPURAM 695011,KERALA,INDIA. REG CANC CTR,DIV MED ONCOL,THIRUVANANTHAPURAM 695011,KERALA,INDIA. REG CANC CTR,DIV RADIAT ONCOL,THIRUVANANTHAPURAM 695011,KERALA,INDIA. DOCTORS DIAGNOST & RES CTR,DEPT PATHOL,THIRUVANANTHAPURAM 695011,KERALA,INDIA.
Abstract:
The extent of cell proliferation is an important biological aspect of a tumor cell population that can affect clinical outcome. Besides other well established clinical and histopathological prognostic criteria, cell kinetic data may therefore be of significant prognostic value. This study evaluated the proliferative activity of various grades of non-Hodgkin's lymphoma, by analyzing the expression of the proliferating cell nuclear antigen (PCNA). PCNA is a 36 kD nuclear protein associated with the cell cycle and is directly involved in DNA synthesis during cell proliferation. Our study revealed a good correlation (p=0.000) between PCNA expression and tumor grade. The highest levels of PCNA expression (mean=43%) were seen in the high grade lesions and the lowest (mean=19%) in low grade lesions. These results suggest that PCNA immunostaining may be used to evaluate proliferative index in various grades of NHL, which in turn could be used to monitor response to treatment.
Related Concept Videos
Abnormal Proliferation
Abnormal Proliferation
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Proliferative Phase
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...
Secondary Lymphoid Organs
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

