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Vitamins A and E in neoplastic disease.

M Broccio¹, F Dellarovere, A Granata

¹UNIV MESSINA,DIPARTIMENTO STAT,I-98147 MESSINA,ITALY. UNIV MESSINA,IST BIOCHIM,I-98147 MESSINA,ITALY. UNIV MESSINA,I-98147 MESSINA,ITALY.

Oncology Reports

|May 19, 2011

Summary

This study found significantly lower levels of vitamins A and E in cancer patients compared to healthy individuals. These essential antioxidants may be depleted due to the oxidative stress associated with neoplastic disease.

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Area of Science:

Biochemistry
Oncology
Nutritional Science

Background:

Vitamins A and E are crucial antioxidants combating free radicals (FRs).
Neoplastic disease (ND) is linked to FRs pathology and increased oxidative stress.
Previous research indicates erythrocyte membrane lipid peroxidation in ND.

Purpose of the Study:

To investigate the levels of vitamins A and E in cancer patients.
To compare vitamin A and E concentrations between neoplastic disease patients and healthy controls.
To explore the relationship between these vitamins and oxidative stress in cancer.

Main Methods:

Simultaneous assay of serum vitamin A and E using high-pressure liquid chromatography (HPLC).
Study included 88 cancer patients and 94 healthy subjects.
HPLC method demonstrated speed, accuracy, and repeatability.

Main Results:

Cancer patients exhibited significantly lower average vitamin A levels (47.44±19.60 μg/dl) compared to controls (71.77±18.30 μg/dl; P<0.0001).
Cancer patients showed significantly lower average vitamin E levels (1144.42±507.45) compared to controls (1497.45±397.74; P<0.0001).
Statistical significance (P<0.0001) was observed for both vitamin deficiencies in cancer cases.

Conclusions:

Serum levels of vitamins A and E are markedly reduced in patients with neoplastic disease.
The decrease in these vitamins may be linked to increased free radical activity and oxidative stress in cancer.
Further research is warranted to understand the reasons for vitamin depletion and its implications in cancer.