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Published on: October 21, 2022
Autocrine motility factor receptor expression as a prognostic factor in pulmonary adenocarcinoma
I Takanami1, S Kodaira, F Tanaka
1TEIKYO UNIV,SCH MED,DEPT PATHOL,TOKYO 173,JAPAN. GUNMA UNIV,SCH MED,DEPT ORTHOPED SURG,GUNMA,JAPAN. MICHIGAN CANC FDN,DEPT CANC METASTASIS PROGRAM,DETROIT,MI 48201.
Abstract:
Autocrine motility factor receptor (AMF-R) expression was studied immunologically in tissue specimens from 121 patients with pulmonary adenocarcinoma. AMF-R expression was correlated with lymph node metastasis and stage. The prognosis of AMF-R positive patients was poorer than that of AMF-R negative patients. Multivariate analysis showed that AMF-R expression had a significant influence on prognosis. Our findings suggest that AMF-R plays an important role in tumor progression and that AMF-R expression is a useful prognostic marker for pulmonary adenocarcinomas.
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