Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Updated EBMT/ESID inborn errors working party guidelines for haematopoietic stem cell transplantation for inborn errors of immunity and metabolism.

Bone marrow transplantation·2026

Same author

How low can we go? Comparison of liberal and restrictive red cell transfusion thresholds in paediatric allogeneic haematopoietic stem cell transplantation: A randomized multicentre feasibility trial.

British journal of haematology·2025

Same author

B-cell depletion abrogates immune mediated cytopenia and rejection of cord blood transplantation in Hurler syndrome.

Bone marrow transplantation·2021

Same author

The evolution of pulmonary function in childhood onset Mucopolysaccharidosis type I.

Molecular genetics and metabolism·2020

Same author

Social media for health promotion in diabetes: study protocol for a participatory public health intervention design.

BMC health services research·2018

Same author

Refining the phenotype associated with biallelic DNAJC21 mutations.

Clinical genetics·2018

Search research articles

Related Experiment Video

Updated: Jun 1, 2026

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

Early stage breast cancer.

C Theodossiou¹, P Schwarzenberger, I Espinozadelgado

¹LOUISIANA STATE UNIV,STANLEY S SCOTT CANC CTR,NEW ORLEANS,LA 70112. LOUISIANA STATE UNIV,MED CTR,NEW ORLEANS,LA 70112.

Oncology Reports

|May 19, 2011

Summary

This review discusses breast cancer treatment advancements. Early-stage diagnoses are increasing, expanding options for adjuvant chemotherapy and hormonal therapy, alongside surgical and radiation guidelines.

More Related Videos

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

Related Experiment Videos

Last Updated: Jun 1, 2026

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

Area of Science:

Oncology
Women's Health
Medical Diagnostics

Background:

Breast cancer is the most prevalent malignancy affecting women globally.
Increased awareness and widespread screening mammography have led to a rise in early-stage diagnoses.
Evolving treatment paradigms have broadened the scope of adjuvant therapies for breast cancer patients.

Purpose of the Study:

To review current prognostic factors influencing breast cancer treatment decisions.
To outline contemporary recommendations for surgical extent and radiation therapy integration.
To present updated guidelines for adjuvant chemotherapy and hormonal therapy.

Main Methods:

Review of current literature and clinical guidelines.
Analysis of prognostic factors in early-stage breast cancer.
Synthesis of multidisciplinary therapeutic approaches.

Main Results:

Growing number of early-stage breast cancer diagnoses.
Expanded indications for adjuvant chemotherapy and hormonal therapy.
Updated recommendations for surgical and radiation oncology integration.

Conclusions:

Multidisciplinary approaches are crucial for tailoring breast cancer treatment.
Adjuvant therapies play a significant role in managing early-stage disease.
Evidence-based guidelines are essential for optimizing patient outcomes in breast cancer care.