Bleeding complications with acute coronary syndrome in six Middle Eastern countries

Area of Science:

• Cardiology
• Clinical Research
• Public Health

Background:

• Limited data exists on major bleeding complications in Middle Eastern acute coronary syndrome (ACS) patients.
• Understanding bleeding prevalence and impact is crucial for improving patient outcomes in the region.

Purpose of the Study:

• To determine the prevalence of major bleeding complications in Middle Eastern ACS patients.
• To investigate the prognostic implications of major bleeding on in-hospital outcomes.

Main Methods:

• Prospective, multinational registry (Gulf RACE) of 8166 patients hospitalized with ACS.
• Patients stratified based on the occurrence of major bleeding complications during index admission.
• Analysis of baseline characteristics, treatments, and in-hospital outcomes.

Main Results:

• Major bleeding occurred in 0.83% of patients, associated with older age and ST-segment elevation myocardial infarction.
• Patients with bleeding had significantly worse in-hospital outcomes, including higher mortality, heart failure, and stroke.
• Major bleeding independently predicted a >5-fold increase in in-hospital mortality (OR 5.2).

Conclusions:

• Bleeding in ACS patients in the Middle East is a significant independent predictor of adverse in-hospital outcomes.
• Findings are consistent with Western studies, emphasizing the universal impact of bleeding.
• Highlights the need for strategies to mitigate bleeding risk in ACS management in the Middle East.