Related Experiment Video
Updated: May 23, 2026
09:29
Fabrication and Implantation of Miniature Dual-element Strain Gages for Measuring In Vivo Gastrointestinal Contractions in Rodents.
Published on: September 18, 2014
Electroacupuncture improves rectal distension-induced delay in solid gastric emptying in dogs
1Division of Gastroenterology, University of Texas Medical Branch, Galveston, Texas, USA.
Summary
Electroacupuncture (EA) effectively treats delayed gastric emptying caused by rectal distension (RD). This therapy may work through the opioid pathway, offering potential for treating digestive issues.
Area of Science:
- Gastroenterology
- Neuroscience
- Acupuncture Research
Background:
- Rectal distension (RD) significantly delays gastric emptying of solids.
- Understanding the mechanisms behind RD-induced gastric stasis is crucial for developing treatments.
Purpose of the Study:
- To investigate the effects of electroacupuncture (EA) on RD-induced delayed gastric emptying in dogs.
- To explore the underlying mechanisms of EA's action, particularly the involvement of the opioid pathway.
Main Methods:
- Gastric emptying was assessed in dogs using a duodenal cannula method to measure solid chyme.
- Experiments included control, RD, sham-EA, and varying intensities of EA (3 mA, 6 mA), with naloxone used to test opioid receptor involvement.
Main Results:
- RD significantly delayed gastric emptying.
- EA, but not sham-EA, attenuated the delay, with 6 mA being more potent than 3 mA.
- The effect of EA was blocked by naloxone, indicating opioid pathway involvement.
Conclusions:
- Electroacupuncture effectively attenuates rectal distension-induced delay in gastric emptying.
- The therapeutic effect of EA in this context appears to be mediated through the opioid pathway.
- EA shows potential as a treatment for delayed gastric emptying linked to lower gut distension.
