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Human cancers express mutator phenotypes: origin, consequences and targeting

Lawrence A Loeb1

  • 1Department of Pathology, University of Washington School of Medicine, Seattle, Washington 98195, USA. laloeb@u.washington.edu

Nature Reviews. Cancer
|May 20, 2011
PubMed

Insights

Cancer cells exhibit a mutator phenotype, accumulating thousands of DNA mutations. This perspective explores the mutator phenotype hypothesis, its implications for personalized cancer medicine, and potential error catastrophe therapies.

Area of Science:

  • Genomics
  • Cancer Biology
  • Molecular Oncology

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