Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Altered States of Awareness

Altered States of Awareness

Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain that...

Tip-of-the-Tongue Phenomenon

Tip-of-the-Tongue Phenomenon

The tip-of-the-tongue (TOT) phenomenon is a cognitive experience characterized by a temporary inability to retrieve specific information from memory despite having a strong feeling of knowing the information. Although individuals cannot access the target word or detail, they frequently recall related elements, such as its initial letter, syllable count, or context. This partial retrieval often causes frustration, as one might recognize a familiar face or know that a name starts with a specific...

Hindsight Biases

Hindsight Biases

Hindsight bias leads you to believe that the event you just experienced was predictable, even though it really wasn’t. In other words, you knew all along that things would turn out the way they did. Can you relate this to the phrase "Hindsight is 20/20" now?

Desensitization and Tachyphylaxis

Desensitization and Tachyphylaxis

Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
Several...

Amnesia

Amnesia

Amnesia is a condition marked by long-term memory loss, which impairs the ability to recall past events or create new memories.
The severity and duration of memory loss vary depending on the type and underlying cause. Amnesia is classified into two main types: retrograde and anterograde.
Retrograde amnesia is marked by the loss of memories formed before the onset of the condition. Patients may recall distant past events but often forget those occurring shortly before the incident.
Anterograde...

Deindividuation

Deindividuation

Deindividuation is a form of social influence on an individual’s behavior such that the individual engages in unusual or non-normal behavior while in a group setting. Why? Because in these group settings, the individual no longer sees themselves as an individual anymore, disinhibiting their behavior and personal restraint.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The Effect of Strontium on Embryonic Calcification of Aplysia californica.

The Biological bulletin·2018

Same author

The effect of weight-loss on estimated breast-cancer risk and sex-hormone levels.

Oncology reports·2011

Same author

Cancer-patients - the survival and expense of traditional care and hospice care.

Oncology reports·2011

Same author

Early stage breast cancer.

Oncology reports·2011

Same author

Heroic measures when treating patients with hematologic malignancies - the economic cost of survival.

International journal of oncology·2011

Same author

Prostate-cancer surveillance - a cost-effective strategy.

International journal of oncology·2011

Same journal

Identification of RRM2 as a key regulator of malignant epithelial cells in gastric cancer through single‑cell transcriptomics.

Oncology reports·2026

Same journal

Impact of WFDC2 on the biological functions of cervical cancer cells and the regulation of the ERK/NF‑κB signaling pathway.

Oncology reports·2026

Same journal

Schisandrin B exhibits anti‑proliferative effects by inducing ferroptosis in pancreatic cancer.

Oncology reports·2026

Same journal

Research advances on DKK1 in head and neck squamous cell carcinoma: Linking molecular mechanisms to clinical applications (Review).

Oncology reports·2026

Same journal

PI3Kδ inhibitor YY‑20394 is effective alone or in combination with Bcl‑2 inhibitor ABT199 in acute myeloid leukemia cells.

Oncology reports·2026

Same journal

A fibroblast activation protein degrader enhances cisplatin sensitivity in non‑small cell lung cancer.

Oncology reports·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 1, 2026

Doppler Optical Coherence Tomography of Retinal Circulation

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

DES-ja vu.

D Schapira¹, L Garland

¹H LEE MOFFITT CANC CTR,TAMPA,FL.

Oncology Reports

|May 20, 2011

Summary

This summary is machine-generated.

High-dose estrogen therapy, specifically diethylstilbestrol, showed significant effectiveness in treating advanced breast cancer in postmenopausal women. This hormonal therapy was well-tolerated, even in heavily pretreated patients.

More Related Videos

Human Fear Conditioning Conducted in Full Immersion 3-Dimensional Virtual Reality

Human Fear Conditioning Conducted in Full Immersion 3-Dimensional Virtual Reality

Published on: August 9, 2010

A Flexible Platform for Monitoring Cerebellum-Dependent Sensory Associative Learning

A Flexible Platform for Monitoring Cerebellum-Dependent Sensory Associative Learning

Published on: January 19, 2022

Related Experiment Videos

Last Updated: Jun 1, 2026

Doppler Optical Coherence Tomography of Retinal Circulation

Doppler Optical Coherence Tomography of Retinal Circulation

Published on: September 18, 2012

Human Fear Conditioning Conducted in Full Immersion 3-Dimensional Virtual Reality

Human Fear Conditioning Conducted in Full Immersion 3-Dimensional Virtual Reality

Published on: August 9, 2010

A Flexible Platform for Monitoring Cerebellum-Dependent Sensory Associative Learning

A Flexible Platform for Monitoring Cerebellum-Dependent Sensory Associative Learning

Published on: January 19, 2022

Area of Science:

Oncology
Endocrinology
Pharmacology

Background:

High-dose estrogen therapy was previously a standard for breast cancer before antiestrogens emerged.
Antiestrogens reduced estrogen use due to lower toxicity, but high-dose estrogen's efficacy remains relevant.

Purpose of the Study:

To evaluate the response rates and toxicities of diethylstilbestrol (DES) in postmenopausal women with advanced breast cancer.
To assess the potential for reintroducing high-dose estrogen therapy in heavily pretreated patients.

Main Methods:

Eight postmenopausal women with advanced breast cancer received diethylstilbestrol (DES) 5 mg orally three times daily.
Patients had been pretreated with multiple hormonal agents and cytotoxic chemotherapy.

Main Results:

50% of patients (4/8) showed objective responses, including complete, partial, and minor responses.
Responses lasted from 3 to 12 months; the therapy was generally well-tolerated.
Two patients had stable disease (25%), and two had progressive disease (25%).

Conclusions:

High-dose estrogen therapy (DES) is effective and safe for advanced breast cancer, even after extensive prior treatments.
Estrogen therapy could be reconsidered in this clinical setting due to its acceptable toxicity profile and efficacy.