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Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...

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Liposarcoma.

M Neuburger1, G Herget, C Adler

  • 1UNIV FREIBURG,INST PATHOL,REFERENZZENTRUM KNOCHENTUMOREN,D-79002 FREIBURG,GERMANY.

Oncology Reports
|May 20, 2011
PubMed
Summary
This summary is machine-generated.

Image cytophotometric measurements (ICM) detected aneuploidy in most liposarcomas, unlike flow cytometry (FCM). ICM may be superior for determining DNA content in liposarcoma, which has prognostic importance.

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Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • Liposarcomas are malignant tumors of adipose tissue.
  • DNA content analysis is crucial for tumor classification and prognosis.
  • Aneuploidy, an abnormal DNA content, is a key indicator of malignancy.

Purpose of the Study:

  • To compare flow cytometry (FCM) and image cytophotometric measurements (ICM) for DNA content analysis in liposarcomas and lipomas.
  • To evaluate the diagnostic accuracy of FCM and ICM in identifying aneuploidy in these tumors.
  • To determine the prognostic significance of DNA content in liposarcoma.

Main Methods:

  • Nuclear suspensions from 7 bone-associated liposarcomas and 3 lipomas were analyzed.
  • DNA content was measured using both FCM and ICM.
  • Aneuploidy was assessed by both methods, and results were compared.

Main Results:

  • ICM identified aneuploidy in 6 of 7 liposarcomas (86%), while FCM detected it in only 3 (43%).
  • No lipomas exhibited aneuploidy with either method.
  • The concordance between FCM and ICM was 70%.

Conclusions:

  • ICM appears more sensitive than FCM in detecting aneuploidy in liposarcomas.
  • Aneuploidy is a significant prognostic factor in liposarcoma.
  • ICM may be the preferred method for DNA content determination in liposarcoma for prognostic assessment.