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Updated: Jun 1, 2026

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Published on: June 18, 2015
Tamoxifen inhibits phorbol ester-induced reactive nitrogen intermediate production by U937 cells
Abstract:
Phorbol 12-myristate 13-acetate (PMA) enhanced nitrite production by U937 cells. During a 6-day treatment of U937 cells with PMA (200 nM-1000 nM) there was a significant increase (p<0.001) in NO2- secreted into the culture medium. Treatment of the same cells with tamoxifen (10(-10) M -10(-6) M) had no effect on nitrite production. However, tamoxifen was able to significantly (p<0.05) down-regulate PMA-enhanced nitrite production by U937 cells.
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