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Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.

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Related Experiment Video

Updated: Jun 1, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

nm23 and p53 expression.

C Midulla1, P Deiorio, C Valli

  • 1UNIV ROMA LA SAPIENZA,INST OBSTET & GYNECOL 1,I-00161 ROME,ITALY.

Oncology Reports
|May 20, 2011
PubMed
Summary
This summary is machine-generated.

Identifying high-risk breast cancer patients is crucial for effective adjuvant therapy. This study examined nm23 and p53 protein expression as prognostic indicators, finding lymph node metastasis remains the most accurate predictor of recurrence.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Pathology

Background:

  • Breast cancer treatment varies based on tumor biology.
  • Identifying high-risk, lymph node-negative patients is key for adjuvant therapy.
  • Prognostic factors guide treatment decisions and improve survival.

Purpose of the Study:

  • To evaluate nm23 antimetastatic gene and p53 protein as prognostic markers in breast cancer.
  • To correlate these markers with established prognostic factors like lymph node status and tumor grade.
  • To determine their utility in identifying patients who would benefit from adjuvant therapy.

Main Methods:

  • Studied nm23 and p53 protein expression in 32 breast cancer patients.
  • Correlated protein expression with lymph node status, hormone receptor status, and histopathologic parameters.
  • Analyzed associations with tumor grade, DNA ploidy, necrosis, and histologic grading.

Main Results:

  • Positive nm23 staining inversely correlated with lymph node involvement (82.4%).
  • High p53 protein expression was observed in 70.8% of non-diploid lesions.
  • p53 positivity (28.1%) strongly correlated with necrosis and histologic grading, but not tumor grade, DNA ploidy, or lymph node metastasis.

Conclusions:

  • nm23 and p53 protein expression provide insights into breast cancer's biologic behavior.
  • Established prognostic indicators, including lymph node metastasis, necrosis, and histologic grading, remain significant.
  • Lymph node metastasis detection is the most accurate prognostic factor for predicting breast cancer recurrence.