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Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
p53 overexpression in oral lichen planus
1FRED HUTCHINSON CANC RES CTR,SEATTLE,WA 98104. SIMON FRASER UNIV,SCH KINESIOL,BURNABY,BC V5A 1S6,CANADA.
Oncology Reports
|May 20, 2011
Summary
Oral lichen planus (OLP) without dysplasia may be premalignant. P53 protein expression in OLP basal cells might regulate apoptosis, not indicate mutation, suggesting a role in OLP progression.
Area of Science:
- Oral pathology
- Oncology
- Immunohistochemistry
Background:
- Oral lichen planus (OLP) is debated as a premalignant lesion.
- The precancerous potential of OLP without dysplasia remains unclear.
Purpose of the Study:
- To investigate the immunohistochemical expression of p53 in OLP lesions lacking dysplasia.
- To explore the potential premalignant nature of OLP without dysplasia.
Main Methods:
- Immunohistochemistry was used to detect p53 expression in OLP samples without dysplasia.
- Single-strand conformation polymorphism-polymerase chain reaction (SSCP-PCR) was performed on p53-positive cases to screen for mutations.
Main Results:
- p53 positive cells were observed in the basal epithelium of 50% of OLP samples without dysplasia.
- SSCP-PCR analysis did not reveal mutations in the p53 gene in the analyzed OLP cases.
Conclusions:
- The p53 expression in OLP without dysplasia may represent wild-type p53 involved in regulating apoptosis due to cell-mediated cytotoxicity.
- p53 stabilization without mutation suggests a potential role in OLP pathogenesis and premalignancy.
