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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Interleukin-6, but not soluble adhesion molecules, predicts a subsequent mortality from cardiovascular disease in

Zhen-Xing Fan1, Qi Hua, Yin-Ping Li

  • 1Department of Cardiology, Xuanwu Hospital, Capital Medical University, Xuanwu District, Beijing, China.

Cell Biochemistry and Biophysics
|May 20, 2011
PubMed

Insights

Elevated interleukin-6 (IL-6) levels upon hospital admission predict long-term cardiovascular mortality in ST-segment elevation myocardial infarction (STEMI) patients. Soluble adhesion molecules did not show similar predictive value.

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Research
  • Biomarker Discovery

Background:

  • Inflammatory responses play a key role in atherosclerosis.
  • Inflammatory markers are potential cardiovascular risk predictors, but data are limited and controversial.
  • Acute ST-segment elevation myocardial infarction (STEMI) necessitates accurate risk stratification for long-term outcomes.

Purpose of the Study:

  • To investigate the predictive value of admission serum levels of interleukin-6 (IL-6) and soluble adhesion molecules (sICAM-1, sVCAM-1, sP-selectin) for 3-year cardiovascular mortality in STEMI patients.
  • To determine if IL-6 or soluble adhesion molecules are independent predictors of cardiovascular death post-STEMI.

Main Methods:

  • Prospective cohort study of 263 first STEMI patients admitted within 6 hours of symptom onset.
  • Serum levels of IL-6, sICAM-1, sVCAM-1, and sP-selectin measured at admission.
  • 3-year follow-up for cardiovascular mortality, analyzed using Kaplan-Meier plots and logistic regression.

Main Results:

  • 34 cardiovascular deaths occurred during follow-up.
  • Admission IL-6 levels were significantly higher in patients who died.
  • sICAM-1, sVCAM-1, and sP-selectin levels were not significantly different between survivors and non-survivors.
  • Higher IL-6 levels correlated with increased cardiovascular mortality (P = 0.0002).

Conclusions:

  • Elevated admission IL-6 levels are a valuable independent predictor of long-term cardiovascular mortality in STEMI patients.
  • Soluble adhesion molecules (sICAM-1, sVCAM-1, sP-selectin) at admission do not appear to predict long-term cardiovascular mortality in this cohort.
  • IL-6 offers important prognostic information for risk assessment in STEMI survivors.

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