Proton MR spectroscopy in herpes simplex encephalitis: assessment of neuronal loss
D K Menon1, J Sargentoni, C J Peden
1NMR Unit, Hammersmith Hospital, London, U.K.
Journal of Computer Assisted Tomography
|May 1, 1990
Abstract:
We present here the case of an 11-year-old boy with herpes simplex encephalitis diagnosed on the basis of clinical features, serology, and response to acyclovir, who relapsed after 3 weeks of therapy. In vivo proton magnetic resonance spectroscopy (1H MRS) of the brain, at 8 and 16 weeks after the onset of symptoms, showed abnormalities, most prominently a reduction in the N-acetylaspartate/choline ratio. The role of 1H MRS in assessing disease activity is discussed.
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