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Updated: Jun 1, 2026
10:41
Continuous High-resolution Microscopic Observation of Replicative Aging in Budding Yeast
Published on: August 20, 2013
Youth is wasted on the young
Marc S Penn1, Martiza E Mayorga, Feng Dong
1Skirball Laboratory for Cardiovascular Cellular Therapeutics, Cleveland Clinic, NE3, 9500 Euclid Avenue, Cleveland, OH 44195, USA. pennm@ccf.org
Stem Cell Research & Therapy
|May 21, 2011
Summary
Neonatal mice can regenerate heart tissue within 7 days after birth, unlike adult mammals. This finding offers new strategies for treating cardiac dysfunction.
Area of Science:
- Cardiovascular biology
- Regenerative medicine
- Developmental biology
Background:
- Amphibians and zebrafish regenerate myocardial tissue, while mammals form scar tissue after injury.
- Adult mammalian cardiac myocytes have limited proliferation, hindering regeneration.
- Neonatal mammalian cardiac myocytes possess limited proliferative capacity.
Purpose of the Study:
- To investigate the regenerative capacity of neonatal mammalian cardiac tissue after injury.
- To determine the age-related loss of cardiac regenerative potential in mammals.
Main Methods:
- Review of recent studies demonstrating cardiac regeneration in neonatal mice.
- Analysis of the proliferative capacity of neonatal versus adult mammalian cardiac myocytes.
Main Results:
- One-day-old neonatal mice demonstrated the ability to regenerate resected cardiac tissue.
- Cardiac tissue regenerative capacity was lost in mice by 7 days after birth.
- This loss of regeneration correlates with developmental changes in cardiac myocytes.
Conclusions:
- Neonatal mammalian hearts possess a limited window for regeneration after injury.
- Understanding this window is crucial for developing therapies for cardiac dysfunction.
- Findings may inform future strategies for preventing and treating heart damage in clinical populations.
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