Related Experiment Video
Updated: Jun 1, 2026

A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn
Published on: April 7, 2023
Patient safety factors in children dying in a paediatric intensive care unit (PICU): a case notes review study
Kim Monroe1, Deli Wang, Charles Vincent
1Northwestern University, Children’s Memorial Hospital, Chicago, Illinois, USA.
Insights
Patient safety issues in pre-paediatric intensive care unit (PICU) hospital care were frequent among children who died. Critical incidents occurred throughout the care pathway, highlighting the need for improved healthcare delivery strategies.
Area of Science:
- Pediatric Critical Care Medicine
- Patient Safety Research
- Healthcare Quality Improvement
Background:
- Critically ill children dying in paediatric intensive care units (PICUs) often experience adverse events during pre-hospital and hospital management.
- Understanding these patient safety factors is crucial for improving outcomes in pediatric critical care.
Purpose of the Study:
- To identify patient safety factors in the pre-hospital and hospital management of critically ill children who died in a PICU.
- To analyze adverse events contributing to death (AEds) and critical incidents (CIs) in this vulnerable population.
Main Methods:
- Retrospective review of case notes from a single tertiary regional PICU in London.
- Analysis of 47 patient deaths (7% of admissions) over two years (2007-2008).
- Defined and categorized adverse events contributing to death (AEds) and critical incidents (CIs).
Main Results:
- 36% of cases had AEds, predominantly related to diagnosis and management of critical illness in pre-PICU hospital care.
- 60% of cases had CIs, occurring across the entire patient journey (pre-hospital, pre-PICU, transport, and PICU).
- Individual, team, and organizational factors were identified as major contributors to both AEds and CIs.
Conclusions:
- Adverse events during pre-PICU hospital care are common and significantly impact outcomes for children who die in the PICU.
- Critical incidents are pervasive throughout the patient's journey, emphasizing systemic issues in care delivery.
- Further interventional studies are essential to develop and implement effective strategies for enhancing patient safety in pediatric critical care.
Objective:
To identify patient safety factors in pre-hospital and hospital management of critically ill children dying in a paediatric intensive care unit (PICU).
Design:
Retrospective case notes review.
Setting:
Single tertiary regional PICU in London.
Participants:
47 patients (7%) who died from a total of 679 children admitted during 2007 and 2008. Median age was 1.1 years and median predicted mortality from the Paediatric Index of Mortality 2 score was 39%.
Main Outcome Measures:
Adverse events contributing to death (AEds) and critical incidents (CIs). AEd was defined as an unintended injury or complication caused by health care management, contributing to death. CI was defined as an undesirable event in healthcare management, which could have led to harm or did lead to harm of the patient but did not contribute to the patient's death.
Results:
22 AEds occurred in 17 of 47 (36%) cases. Two AEds occurred in primary care, 20 in pre-PICU hospital care, and none in PICU. AEds were mainly problems in diagnosis and management of critical illness. 37 CIs occurred in 28 of 47 (60%) cases. Two CIs occurred prior to hospital admission, 17 occurred in pre-PICU hospital care, 1 during inter-hospital transport and 17 in PICU. CIs were predominantly medical management and procedure related. Individual, team and organisational factors caused the majority of AEds and CIs.
Conclusion:
Adverse events in pre-PICU hospital care were common in children who subsequently died in PICU. CIs occurred throughout the patient journey. Interventional studies of healthcare organisation and delivery are necessary to identify appropriate strategies to improve patient safety.
Related Concept Videos
Pharmacokinetics in Pediatric Patients: Drug Distribution
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Pharmacokinetics in Pediatric Patients: Drug Excretion
Pharmaceutical Poisoning: Potential Scenarios
Pneumonia III: Complications and Assessment
Acute Kidney Injury V: Interprofessional Care
