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Updated: Jun 1, 2026

A Mouse Model for Laser-induced Choroidal Neovascularization
Published on: December 27, 2015
[Effects of carteolol hydrochloride on experimental choroidal neovascularization]
Susumu Ishida1, Hiroshi Mochimaru, Norihiro Nagai
1Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. ishidasu@med.hokudai.ac.jp
Purpose:
To investigate the effects of carteolol hydrochloride on choroidal neovascularization (CNV).
Methods:
Laser photocoagulation was performed to induce CNV in C 57 BL/6 mice. The response of CNV was assessed by fluorescein isothiocyanate-isolectin B 4 staining. The expression of intercellular adhesion molecule (ICAM)-1 and monocyte chemotactic protein (MCP)-1 in the retinal pigment epithelium (RPE)-choroid complex and tumor necrosis factor (TNF)-alpha in the RAW 264.7 macrophage culture was evaluated by enzyme-linked immunosorbent assay.
Results:
Carteolol hydrochloride application led to significant suppression of the generation of CNV, the production of ICAM-1 and MCP-1 in the RPE-choroid, and macrophage expression of TNF-alpha.
Conclusion:
Carteolol hydrochloride prevented CNV development through its anti-inflammatory action.
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