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The early repolarization pattern in the general population: clinical correlates and heritability
Peter A Noseworthy1, Jani T Tikkanen, Kimmo Porthan
1Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA.
Journal of the American College of Cardiology
|May 24, 2011
Summary
Early repolarization pattern (ERP) is linked to clinical factors and shows heritability in the general population. This suggests a genetic basis for ERP, warranting further investigation into its genetic determinants.
Area of Science:
- Cardiology
- Genetics
- Epidemiology
Background:
- Growing recognition of early repolarization pattern (ERP) association with adverse cardiovascular outcomes.
- Understanding the clinical correlates and heritability of ERP is crucial for risk stratification.
Purpose of the Study:
- To describe the clinical correlates of early repolarization pattern (ERP).
- To investigate the heritability of ERP in population-based cohorts.
Main Methods:
- Analysis of two large cohorts: Framingham Heart Study (FHS) and Health 2000 Survey (H2K).
- ERP defined as J-point elevation ≥0.1 mV in inferior or lateral leads.
- Assessment of clinical characteristics and sibling recurrence risk for ERP.
Main Results:
- ERP prevalence was 6.1% in FHS and 3.3% in H2K.
- Independent correlates of ERP included male sex, younger age, lower systolic blood pressure, and specific ECG voltage criteria.
- Siblings of individuals with ERP showed increased prevalence (11.6%) and odds (OR 2.22) of ERP.
Conclusions:
- Early repolarization pattern (ERP) demonstrates significant associations with clinical factors.
- Evidence suggests a heritable basis for ERP in the general population.
- Further research into the genetic determinants of ERP is recommended.
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