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A synthetic iterative pathway for ketoacid elongation

C R Shen1, J C Liao

  • 1Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, California, USA.

Methods in Enzymology
|May 24, 2011
PubMed
Summary

Researchers engineered Escherichia coli enzymes (LeuABCD) to iteratively elongate 2-ketoacids. This synthetic module successfully extended carbon chains, demonstrating a novel strategy for creating nonnative metabolites.

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