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Related Experiment Video

Updated: Jun 1, 2026

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

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Published on: December 12, 2019

ApoER2 and VLDLR in the developing human telencephalon.

Lin Cheng¹, Zhiliang Tian, Ruizhen Sun

¹Department of Histology and Embryology, Harbin Medical University, Harbin 150081, Heilongjiang Province, China.

European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society

|May 24, 2011

Summary

The Reelin-Dab1 pathway guides cortical neuron migration. ApoER2 and VLDLR receptors are crucial, with ApoER2 initiating activity in developing human brain neurons.

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Published on: March 25, 2022

Area of Science:

Neuroscience
Developmental Biology
Cell Biology

Background:

The Reelin-Dab1 signaling pathway is vital for cerebral cortex development, regulating neuronal migration and positioning.
Mutations in Reelin are linked to severe developmental disorders like lissencephaly.
Apolipoprotein E receptor type-2 (ApoER2) and very low-density lipoprotein receptor (VLDLR) are key receptors mediating Reelin signaling.

Purpose of the Study:

To investigate the expression patterns of ApoER2 and VLDLR in the developing human brain.
To understand the role of these receptors in the Reelin-Dab1 pathway during human cortical development.

Main Methods:

Immunocytochemical staining was used to examine ApoER2 and VLDLR expression.
Human fetal brains from 6-18 gestational weeks were analyzed.

Main Results:

Both ApoER2 and VLDLR were absent in the preplate and early cortical plate.
ApoER2 expression preceded VLDLR expression in later stages of cortical plate development.
The Reelin-Dab1 pathway appears to require only ApoER2 for initial activity.

Conclusions:

The Reelin-Dab1 pathway may not be involved in the formation of the preplate and deep cortical plate layers.
This pathway likely influences neurons destined for the superficial cortical layers.
ApoER2 plays a critical role in initiating Reelin pathway activity during human brain development.