[Neurophysiologic and pathomorphologic characteristics of the development of alcoholism (experimental study)]

The neurophysiological and pathomorphological characteristics of experimental alcoholism formation were studied in chronic experiments with 30 rats using a method of recording the electrical activity of different brain structures, the reaction of self-stimulation of the ventrolateral hypothalamus, amygdala and reticular formation of the midbrain, ECG, arterial pressure, conditioned reflexes, review and specialized histochemical methods. Derangements of the electrical activity of the brain, conditioned reflexes, emotional and cardiovascular reactions shared by the limbicoreticular structures and neocortex were found to be dependent on the time of alcoholization. Comparison of the neurophysiological and pathomorphological alterations in the brain seen in experimental alcoholism points to the structural and functional disorders contributing to the failure of the compensatory and adaptation mechanisms.