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Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily regulated...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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Related Experiment Video

Updated: Jun 1, 2026

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
08:42

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

Lrp5 functions in bone to regulate bone mass.

Yajun Cui1, Paul J Niziolek, Bryan T MacDonald

  • 1Orthopedic Research Laboratories, Department of Orthopedic Surgery, Children's Hospital, Boston, Massachusetts, USA.

Nature Medicine
|May 24, 2011
PubMed
Summary
This summary is machine-generated.

Mutations in low-density lipoprotein receptor-related protein 5 (LRP5) affect bone mass. LRP5 signaling acts locally in bone cells, suggesting it could be a target for treating low bone mass disorders like osteoporosis.

Related Experiment Videos

Last Updated: Jun 1, 2026

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
08:42

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

Area of Science:

  • Bone biology
  • Genetics
  • Skeletal development

Background:

  • Low-density lipoprotein receptor-related protein 5 (LRP5) is crucial for skeletal development and bone mass regulation in humans.
  • Mutations in LRP5 are linked to various bone mass phenotypes, including high bone mass and osteoporosis.
  • Understanding the precise role of LRP5 in different bone cell types is essential for developing targeted therapies.

Purpose of the Study:

  • To investigate the function of LRP5 signaling in osteocytes, the primary cells within bone tissue.
  • To determine if LRP5 mutations specifically affect appendicular versus axial skeleton properties.
  • To explore the potential of modulating LRP5 signaling in mature bone cells for therapeutic benefit.

Main Methods:

  • Generated transgenic mice with inducible, osteocyte-specific Lrp5 mutations mimicking human high and low bone mass conditions.
  • Induced Lrp5 mutations in cells forming the appendicular skeleton but not the axial skeleton.
  • Compared bone properties in genetically modified mice to those with inherited mutations.

Main Results:

  • Bone properties in mice with inducible, osteocyte-specific Lrp5 mutations mirrored those with inherited mutations.
  • Altered bone properties were observed in the appendicular skeleton (limbs) but not the axial skeleton (spine) when Lrp5 mutation was induced in limb-specific cells.
  • These findings confirm the local action of LRP5 signaling within bone.

Conclusions:

  • LRP5 signaling exerts a localized effect on bone properties, primarily within the appendicular skeleton.
  • Targeting LRP5 signaling in mature bone cells presents a potential therapeutic strategy for conditions characterized by low bone mass, such as osteoporosis.
  • Further research into LRP5 modulation could lead to novel treatments for skeletal disorders.