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Bradykinin stimulates prostaglandin E2 formation in isolated human osteoblast-like cells
O Ljunggren1, J Rosenquist, M Ransjö
1Department of Oral Pathology, University of Umeå, Sweden.
Bioscience Reports
|February 1, 1990
Abstract:
The effect of bradykinin on prostaglandin E2 formation in cells from human trabecular bone has been studied. The cells responded to parathyroid hormone with enhanced cyclic AMP formation and were growing as cuboidal-shaped, osteoblast-like cells. In these isolated human osteoblast-like cells, bradykinin (1 mumol/l) caused a rapid (5 min) stimulation of prostaglandin E2 formation. This finding indicates that human osteoblasts are equipped with receptors for bradykinin linked to an increase in prostaglandin formation.