Fructose-1,6-diphosphate as an in vitro and in vivo anti-alcohol agent in the rat
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L Galzigna1, M Bianchi, V Rizzoli
1Department of Biological Chemistry, University of Padova, Italy.
Cell Biochemistry and Function
|January 1, 1990
Abstract:
Fructose-1, 6-diphosphate (FDP) decreases the effect of ethanol on Ca++ entry and inhibits the ethanol-stimulated phosphate efflux in rat heart slices. FDP also inhibits the ethanol-stimulated [36Cl-]-uptake by rat brain microvesicles and affects the isolated GABA-receptor in a way opposite to that of ethanol. The in vivo effects of FDP include a dose-dependent decrease in ethanol-induced gastric ulcers and a decrease in the serum transaminase levels raised by chronic ethanol administration. Other central actions of ethanol such as diuresis, narcosis, dependence and withdrawal symptoms are also counteracted by FDP.