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Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although vasectomy...

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Mouse Model of Surgical Uterine Injury and Subsequent Pregnancy Outcomes
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Published on: June 27, 2025

Does dilation and curettage affect future pregnancy outcomes?

Jennifer Lohmann-Bigelow, Sherri A Longo, Xiaozhang Jiang

    Ochsner Journal
    |May 24, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Dilation and curettage (D&C) may increase the risk of postpartum hemorrhage in future pregnancies. However, D&C does not appear to affect other pregnancy outcomes like preterm delivery or preeclampsia.

    Keywords:
    Abortioncurettagedilationmiscarriage

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    Area of Science:

    • Reproductive Medicine
    • Obstetrics and Gynecology

    Background:

    • Dilation and curettage (D&C) is a common surgical procedure for managing miscarriage and other gynecological conditions.
    • The potential impact of D&C on subsequent pregnancy outcomes requires further investigation.

    Purpose of the Study:

    • To evaluate the effect of dilation and curettage on future pregnancy outcomes.
    • To identify specific complications that may be associated with prior D&C procedures.

    Main Methods:

    • Retrospective review of electronic medical records for patients who underwent D&C between 2002 and 2006.
    • Analysis of pregnancy outcomes in patients with at least one subsequent pregnancy.
    • Statistical comparison (Chi-square and Fisher's exact tests) of complication rates with reported data.

    Main Results:

    • A significantly higher incidence of postpartum hemorrhage was observed compared to historical averages (p < 0.0004).
    • No significant differences were found in the rates of preterm delivery, preeclampsia, placental abruption, malpresentation, cervical incompetence, first-trimester bleeding, or miscarriage.
    • Pregnancy outcomes did not differ significantly between patients with and without a history of cervical dilation.

    Conclusions:

    • Dilation and curettage may be a risk factor for postpartum hemorrhage in subsequent pregnancies.
    • Surgical management of miscarriage, including D&C, warrants consideration regarding its long-term effects on reproductive health.