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Related Experiment Video

Updated: Jun 1, 2026

A Microfluidic-based Hydrodynamic Trap for Single Particles

A Microfluidic-based Hydrodynamic Trap for Single Particles

Published on: January 21, 2011

Particle manipulation in a microfluidic channel using acoustic trap.

Jong Seob Jeong¹, Jung Woo Lee, Chang Yang Lee

¹Department of Medical Biotechnology, College of Life Science and Biotechnology, Dongguk University-Seoul, Seoul, 100-715, Republic of Korea. jjsspace@gmail.com

Biomedical Microdevices

|May 24, 2011

Summary

Researchers used focused ultrasound to control particle movement in microfluidic devices. This acoustic trapping method shows promise for developing advanced flow cytometry and cell sorting technologies.

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Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics

Fabrication, Operation and Flow Visualization in Surface-acoustic-wave-driven Acoustic-counterflow Microfluidics

Published on: August 27, 2013

Area of Science:

Acoustic manipulation
Microfluidics
Biotechnology

Background:

Particle manipulation in microfluidic devices is crucial for various applications.
Existing methods for particle control can be complex or limited in scope.
Developing precise, non-invasive control mechanisms is an ongoing challenge.

Purpose of the Study:

To investigate the use of a focused high-frequency sound beam for controlling particle motion within a microfluidic system.
To demonstrate the feasibility of acoustic trapping and manipulation of droplets in microchannels.
To explore the potential of this technique for advanced biological separation applications.

Main Methods:

A 24 MHz lead zirconate titanate (PZT) transducer with a 1-3 piezocomposite structure was used to generate a focused ultrasound beam.
The transducer was excited by a chirp signal (18-30 MHz) with a 50% duty factor.
A polydimethylsiloxane (PDMS) microfluidic device with three subchannels was used to flow and manipulate 60-70 micrometer droplets.

Main Results:

A focused sound beam successfully trapped single droplets (60-70 micrometers) near a channel bifurcation.
The acoustic trap allowed for the controlled diversion of trapped droplets into sheath flow.
The study demonstrated precise control over droplet movement using acoustic forces.

Conclusions:

Focused ultrasound is a viable method for controlling particle and droplet motion in microfluidic devices.
This acoustic manipulation technique has significant potential for developing ultrasound-based flow cytometry and cell sorting.
The findings pave the way for novel non-invasive particle manipulation strategies in microscale systems.