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Updated: Jun 1, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Endothelial dysfunction predicts clinical restenosis after percutaneous coronary intervention
Peter Scott Munk1, Noreen Butt, Alf Inge Larsen
1Department of Cardiology, Stavanger University Hospital, Stavanger, Norway. munk@lyse.net
Insights
Impaired endothelial function, measured by flow-mediated vasodilation, four weeks after percutaneous coronary intervention (PCI) with stenting can predict clinical restenosis in patients with coronary artery disease.
Area of Science:
- Cardiology
- Vascular Biology
- Interventional Cardiology
Background:
- Endothelial dysfunction is linked to cardiovascular events and in-stent restenosis post-percutaneous coronary intervention (PCI).
- Predicting restenosis is crucial for managing patients with coronary artery disease.
Purpose of the Study:
- To determine if endothelial dysfunction predicts clinical and angiographic restenosis after PCI with stenting.
- To assess the predictive value of flow-mediated vasodilation for restenosis in patients undergoing PCI for angina or acute coronary syndrome.
Main Methods:
- One hundred patients with single-vessel disease undergoing successful PCI with stenting were included.
- Brachial artery reactivity (flow-mediated vasodilation) was assessed at four weeks post-PCI.
- Patients were followed for 18 months for clinical or angiographic restenosis, with exercise stress tests at six months.
Main Results:
- Twenty patients experienced clinical restenosis within 18 months.
- Impaired flow-mediated vasodilation (5.8 ± 3.4%) was observed in patients with clinical restenosis versus those without (9.0 ± 4.8%, p = 0.005).
- Flow-mediated vasodilation was the sole independent predictor of clinical restenosis risk (OR 4.5, 95% CI 1.11–17.8) in multivariate analysis.
Conclusions:
- Reduced flow-mediated vasodilation four weeks post-PCI is an independent predictor of clinical restenosis.
- Early assessment of endothelial function may aid in identifying patients at higher risk for restenosis after stenting.
Background:
Endothelial dysfunction is associated with increased risk for cardiovascular events in patients with coronary artery disease and may predict in-stent restenosis after percutaneous coronary intervention. We evaluated if endothelial dysfunction could predict clinical and angiographic restenosis in patients after percutaneous coronary intervention with stent implantation for angina pectoris or acute coronary syndrome.
Methods:
One hundred patients were consecutively included after successful percutaneous coronary intervention with stenting for angiographic single vessel disease. All patients were evaluated with ultrasound detection of brachial artery reactivity at four weeks and with a symptom limited exercise stress test at six months and were followed for the occurrence of clinical or angiographic restenosis for 18 ± 6 months.
Results:
Twenty patients showed clinical signs of restenosis during 18 months follow-up and were referred to re-angiography. Patients with clinical restenosis had impaired flow mediated vasodilation compared to patients without clinical restenosis (5.8 ± 3.4 vs. 9.0 ± 4.8, p = 0.005). In multivariate analysis flow mediated vasodilation was the only independent predictor for the risk of clinical restenosis (OR 4.5, 95% CI 1.11 to 17.8).
Conclusions:
Impaired flow mediated vasodilation four weeks after percutaneous coronary intervention independently predicts the risk of clinical restenosis.
