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Updated: Jun 1, 2026

Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
Diagnosis and clinical features of pemphigus foliaceus
Kirk A James1, Donna A Culton, Luis A Diaz
1Department of Dermatology, University of North Carolina at Chapel Hill, 405 Mary Ellen Jones Building, CB#7287, Chapel Hill, NC 27599-7287, USA.
Abstract:
Pemphigus foliaceus is an acquired autoimmune blistering disease in which the body's immune system produces IgG autoantibodies that target the intercellular adhesion glycoprotein desmoglein-1, which is principally expressed in the granular layer of the epidermis, resulting in the loss of intercellular connections between keratinocytes (acantholysis) and the formation of subcorneal blisters within the epidermis. This article summarizes the epidemiology, clinical features, techniques for diagnosis, and drugs associated with treatment of this rare disease.
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