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Updated: Jun 1, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Pathogenesis of endemic pemphigus foliaceus
Valeria Aoki1, Joaquim Xavier Sousa, Luis A Diaz
1Department of Dermatology, University of São Paulo Medical School, Avenida Doutor Eneas de Carvalho Aguiar, 255 Sala 3016 ICHC, São Paulo CEP 05403-002, Brazil. valeria.aoki@gmail.com
Abstract:
Pemphigus refers to a group of human autoimmune blistering diseases involving skin and/or mucous membranes. Endemic pemphigus foliaceus (EPF), or fogo selvagem is an organ-specific autoimmune blistering disease, first reported in the beginning of the 20th century in rural areas of Brazil. The disease follows the course of streams and creeks, and vanishes after urbanization of the endemic areas. The auto-antigen related to EPF is desmoglein 1, a 160 kDa glycoprotein of the desmossomal core, targeted by in situ and circulating IgG autoantibodies, mainly of the IgG4 subclass.
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