Anticancer Evaluation of Adiantum venustum Don

Area of Science:

• Pharmacology and Toxicology
• Natural Product Chemistry
• Cancer Biology

Background:

• Cancer is a leading cause of mortality worldwide, characterized by uncontrolled cell growth.
• Adiantum venustum Don is a plant with potential medicinal properties.
• Ehrlich Ascites Carcinoma (EAC) is a commonly used animal model for cancer research.

Purpose of the Study:

• To conduct a preliminary phytochemical screening of Adiantum venustum Don.
• To evaluate the anticancer activity of Adiantum venustum Don extract against Ehrlich Ascites Carcinoma.
• To investigate the potential mechanisms underlying the observed anticancer effects.

Main Methods:

• Phytochemical screening of the ethanolic extract of Adiantum venustum Don.
• Administration of the ethanolic extract to EAC-bearing mice.
• Assessment of tumor growth, survival rate, and lipid peroxidation levels.

Main Results:

• The ethanolic extract of Adiantum venustum Don demonstrated significant anticancer activity.
• Phytochemical analysis revealed the presence of terpenoids and flavonoids.
• The extract effectively reduced elevated lipid peroxidation levels in EAC-bearing mice.

Conclusions:

• Ethanolic extract of Adiantum venustum Don exhibits potent anticancer effects.
• Terpenoids and flavonoids present in the extract may contribute to its anticancer activity.
• Adiantum venustum Don holds promise for therapeutic applications in cancer treatment.