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Updated: Jun 1, 2026
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Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue
Published on: July 17, 2018
Adipose tissue-derived progenitor cells and cancer
Yan Zhang1, Charles F Bellows, Mikhail G Kolonin
1Yan Zhang, Mikhail G Kolonin, Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Health Science Center at Houston, Houston, TX 77030, United States.
World Journal of Stem Cells
|May 25, 2011
Summary
Obesity promotes cancer progression by influencing cancer stem cells. Adipose stem cells (ASCs) from white adipose tissue (WAT) may link obesity and cancer by secreting factors that stimulate tumor growth and blood vessel formation.
Area of Science:
- Oncology
- Stem Cell Biology
- Metabolic Research
Background:
- Obesity, characterized by white adipose tissue (WAT) overgrowth, complicates cancer progression.
- Mechanisms linking obesity to cancer risk and progression are not fully understood.
- White adipose tissue (WAT) cells secrete adipokines that may stimulate tumor growth.
Purpose of the Study:
- To review the role of progenitor cell recruitment in cancer progression.
- To emphasize the implications of obesity-expanded progenitors in cancer.
- To explore the link between adipose stem cells (ASCs) and cancer.
Main Methods:
- Literature review of studies on stem cell recruitment in cancer.
- Analysis of animal models investigating adipose stem cells (ASCs) and tumor growth.
- Examination of research on adipokines secreted by ASCs.
Main Results:
- Adipose stem cells (ASCs) from white adipose tissue (WAT) may link obesity and cancer.
- ASCs can promote tumor growth by aiding angiogenesis (new blood vessel formation).
- ASCs migrate from WAT to tumors, modulating the tumor microenvironment.
Conclusions:
- Progenitor cell recruitment, particularly ASCs expanded in obesity, has implications for cancer progression.
- ASCs may contribute to cancer via paracrine signaling within the tumor microenvironment.
- Further research is needed to understand the complex interplay between obesity, ASCs, and cancer.
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