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A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

[Chronic inflammation and biomarkers. Is ageing an expression of chronic inflammation?]

D Schmidt1, A Kwetkat, M Gogol

  • 1Klinik für Geriatrie, Krankenhaus Lindenbrunn, Lindenbrunn 1, Coppenbrügge, Germany. geriatrie@krankenhaus-lindenbrunn.de

Zeitschrift Fur Gerontologie Und Geriatrie
|May 25, 2011
PubMed

Insights

Aging variability is linked to cardiovascular disease and chronic inflammation, termed "inflammageing". Biomarkers like C-reactive protein and interleukin-6 are associated, but inflammageing

Area of Science:

  • Gerontology and immunology.
  • Cardiovascular disease research.

Context:

  • Aging exhibits significant interindividual and intraindividual variability.
  • Subclinical and clinical cardiovascular diseases are known accelerators of the aging process.
  • The concept of "inflammageing" proposes aging as a chronic inflammatory process.

Purpose:

  • To explore the relationship between cardiovascular diseases, inflammation, and the aging process.
  • To discuss the role of various biomarkers in the context of inflammageing.
  • To evaluate the potential of inflammageing as a model for aging and its prognostic utility.

Summary:

  • Aging is characterized by variability and accelerated by cardiovascular diseases, suggesting a link to chronic inflammation or "inflammageing".
  • Biomarkers such as C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), fibrinogen, albumin, and serum amyloid A (SAA) are associated with inflammageing.
  • Connections are observed with immunosenescence, viral infections, oxidative stress markers, and genetic factors.

Impact:

  • Current evidence suggests inflammageing biomarkers are not yet definitive for determining aging or prognosis.
  • Further research is required to validate inflammageing as a comprehensive model for aging or as a consequence of other mechanisms.
  • Understanding inflammageing may offer new insights into age-related diseases and interventions.

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