Electrical conduction block in large nerves: high-frequency current delivery in the nonhuman primate
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Updated: Jun 1, 2026

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat
Published on: November 21, 2025
D Michael Ackermann1, Christian Ethier, Emily L Foldes
1Cleveland FES Center, Hamman 601, 2500 MetroHealth Drive, Cleveland, Ohio 44109, USA. dma18@case.edu
Abstract:
Recent studies have made significant progress toward the clinical implementation of high-frequency conduction block (HFB) of peripheral nerves. However, these studies were performed in small nerves, and questions remain regarding the nature of HFB in large-diameter nerves. This study in nonhuman primates shows reliable conduction block in large-diameter nerves (up to 4.1 mm) with relatively low-threshold current amplitude and only moderate nerve discharge prior to the onset of block.
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