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Related Concept Videos

Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Life Tables01:22

Life Tables

A life table is a statistical tool that summarizes the mortality and survival patterns of a population, providing detailed insights into the likelihood of survival or death across different age intervals within a cohort. By organizing data on survival probabilities and mortality rates, life tables offer a clear snapshot of population dynamics over time. They are extensively used in demography, public health, actuarial science, and ecology to analyze life expectancy, design health interventions,...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

GiSAO.db: a database for ageing research.

Edith Hofer1, Gerhard T Laschober, Matthias Hackl

  • 1Division for Bioinformatics, Biocenter, Innsbruck Medical University, Schöpfstrasse, Austria.

BMC Genomics
|May 26, 2011
PubMed
Summary
This summary is machine-generated.

Researchers developed GiSAO.db, a database for managing ageing research data. This system organizes gene expression, apoptosis, and oxidative stress data for easier analysis of ageing mechanisms.

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09:43

Databases to Efficiently Manage Medium Sized, Low Velocity, Multidimensional Data in Tissue Engineering

Published on: November 22, 2019

Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Understanding the genetic mechanisms of ageing requires analyzing age-related gene expression patterns across species.
  • Effective analysis necessitates organized storage and easy access to large volumes of expression profile data.

Purpose of the Study:

  • To develop a centralized, web-based database system for managing and retrieving ageing-related experimental data.
  • To facilitate the analysis of gene expression and related data in ageing research.

Main Methods:

  • GiSAO.db (Genes involved in senescence, apoptosis and oxidative stress database) stores gene and miRNA expression data, annotations, orthologs, and follow-up experiment data.
  • A user-friendly web application provides data access, incorporating KEGG pathways and external database links.
  • Search and export functions enable efficient data retrieval and further processing.

Main Results:

  • A centralized database, GiSAO.db, has been established for ageing research data management.
  • The database integrates diverse data types, including gene expression, senescence, apoptosis, and oxidative stress information.
  • Incorporation of KEGG pathways and external links enhances data comprehensiveness.

Conclusions:

  • GiSAO.db is a well-suited centralized database for managing ageing research data.
  • The database is accessible online at https://gisao.genome.tugraz.at.
  • All stored data can be accessed using a guest account.