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Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Published on: February 6, 2019

[Brachytherapy in paediatric sarcoma].

Christine Haie-Meder1, Hélène Martelli, Isabelle Dumas

  • 1Institut Gustave-Roussy, service de curiethérapie, 114, rue Édouard-Vaillant, 94800 Villejuif, France.

Bulletin Du Cancer
|May 26, 2011
PubMed
Summary
This summary is machine-generated.

Brachytherapy offers precise radiation for pediatric cancers like rhabdomyosarcoma, sparing healthy tissues. This review details techniques, outcomes, and future directions for this specialized cancer treatment.

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Pediatric Oncology

Context:

  • Brachytherapy use in pediatric malignancies is limited, often confined to specialized centers.
  • Significant variation exists in brachytherapy techniques, modalities (low dose-rate, high dose-rate, pulsed dose-rate), doses, and indications across institutions.

Purpose:

  • To review brachytherapy techniques and indications for pediatric malignancies based on tumor site.
  • To analyze current brachytherapy outcomes and discuss future perspectives in pediatric cancer treatment.

Summary:

  • Brachytherapy, a precise radiation technique, is valuable in treating pediatric cancers, particularly gynecological and prostate/bladder rhabdomyosarcomas, and soft-tissue sarcomas.
  • Its ballistic properties allow for high radiation doses to the tumor while minimizing damage to surrounding normal tissues.
  • The review highlights the need for a multidisciplinary approach in applying brachytherapy for pediatric malignancies.

Impact:

  • Provides a comprehensive overview of brachytherapy applications in pediatric oncology.
  • Identifies key tumor sites and treatment variations, informing clinical practice.
  • Highlights the potential of brachytherapy for improved outcomes and normal tissue sparing in children with cancer.