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Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

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Insulin concentrations in dogs with hypoadrenocorticism.

A G Gow¹, D J Gow, R Bell

¹Royal (Dick) School of Veterinary Studies, The Roslin Institute, Division of Clinical Sciences, The University of Edinburgh, Hospital for Small Animals, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK. adam.gow@ed.ac.uk

Research in Veterinary Science

|May 27, 2011

Summary

In dogs with hypoadrenocorticism, high potassium levels did not stimulate insulin release to lower glucose as hypothesized. This study found no evidence of insulin

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Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice

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Area of Science:

Veterinary Medicine
Endocrinology
Canine Health

Background:

Hypoglycaemia (low blood glucose) is common in dogs with hypoadrenocorticism (Addison's disease).
Insulin plays a key role in regulating both potassium and glucose levels within cells.

Purpose of the Study:

To investigate if hyperkalaemia (high blood potassium) in canine hypoadrenocorticism triggers insulin release.
To determine if this insulin release serves as a protective mechanism to lower glucose and shift potassium into cells.

Main Methods:

Serum insulin concentrations were measured in 11 hyperkalaemic dogs with hypoadrenocorticism.
Insulin levels were compared to those of 33 dogs with non-adrenal illnesses.

Main Results:

No significant difference in serum insulin concentrations was found between dogs with hypoadrenocorticism and the control group.
No correlation was observed between insulin and potassium levels in the hypoadrenal dogs.

Conclusions:

The hypothesis that hyperkalaemia stimulates insulin release in canine hypoadrenocorticism was not supported.
Other factors like pH and osmolality might influence these metabolic processes, potentially masking an insulin effect.