Related Experiment Video
Updated: Aug 10, 2026

Induction of an Inflammatory Response in Primary Hepatocyte Cultures from Mice
Published on: March 10, 2017
ACTH response induced by interleukin-1 is mediated by CRF secretion stimulated by hypothalamic PGE
T Watanabe1, A Morimoto, Y Sakata
1Department of Physiology, Yamaguchi University School of Medicine, Japan.
Abstract:
We investigated whether hypothalamic prostaglandin E2 (PGE2) and corticotropin releasing factor (CRF) are responsible for the development of the adrenocorticotropic hormone (ACTH) response induced by interleukin-1 alpha (IL-1 alpha). The present results show that ACTH responses induced by intravenous injection of IL-1 alpha were suppressed by systemic pretreatment with indomethacin and that intrahypothalamic injection of PGE2 stimulates the secretion of ACTH. Furthermore, systemic pretreatment with anti-CRF antibody significantly suppressed the ACTH response induced by intrahypothalamic injection of PGE2. These data suggest that the ACTH response induced by IL-1 is mediated by CRF secretion stimulated by hypothalamic PGE2.
Related Concept Videos
Hypothalamic-Pituitary Axis
GPCRs Regulate Adenylyl Cylase Activity
Two...
Regulation of Hormone Secretion
Humoral stimuli,...
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Cushing Syndrome II: Pathophysiology
Inflammatory Bowel Disease III: Crohn's Disease

