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Dosage Regimen: Fixed Dose

Dosage Regimen: Fixed Dose

Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...

Rational Dosage Regimen: Maintenance Dose and Loading Dose

Rational Dosage Regimen: Maintenance Dose and Loading Dose

A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady state,...

Dosage Regimens: Designs and Approaches

Dosage Regimens: Designs and Approaches

Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...

Dosage Regimen: Individualization

Dosage Regimen: Individualization

Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...

Dose Size and Dosing Frequency: Determination Methods

Dose Size and Dosing Frequency: Determination Methods

Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...

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Related Experiment Video

Updated: Jun 1, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Dose management in CT facility.

V Tsapaki¹, M Rehani

¹Medical Physics Unit, Konstantopoulio Agia Olga Hospital, Athens, Greece.

Biomedical Imaging and Intervention Journal

|May 27, 2011

Summary

This summary is machine-generated.

Computed Tomography (CT) use has surged, increasing patient radiation dose. This review examines CT advances, their dose impact, and methods for radiation dose optimization in medical imaging.

Keywords:

Patient doses in computed tomography (CT)dose management in CT dose optimisation in CT

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

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Published on: August 30, 2018

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Last Updated: Jun 1, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Area of Science:

Radiology
Medical Physics
Diagnostic Imaging

Background:

Computed Tomography (CT) examinations have significantly increased.
Advances include spiral, multidetector-row, CT fluoroscopy, and PET-CT.
This rise has led to a substantial increase in collective radiation dose.

Purpose of the Study:

To review fundamental CT principles.
To outline recent technological advancements in CT.
To suggest methods for optimizing patient radiation dose.

Main Methods:

Review of basic Computed Tomography (CT) principles.
Analysis of recent technological advances in CT imaging.
Examination of the impact of these advances on patient radiation dose.

Main Results:

CT advancements have led to increased patient radiation exposure.
Image quality often exceeds diagnostic requirements, leading to unnecessary dose.
Standardization of CT procedures is challenging due to varied parameters and applications.

Conclusions:

Optimizing radiation dose in CT is crucial.
Technological advances necessitate a review of CT principles and dose reduction strategies.
Implementing dose optimization methods can mitigate risks associated with increased CT utilization.