Related Experiment Videos
The retinoic acid receptors
H de Thé1, P Tiollais, A Dejean
1Unité de Recombinaison et d'Expression Génétique (INSERM U163/CNRS UA 271), Institut Pasteur, Paris, France.
Nouvelle Revue Francaise D'Hematologie
|January 1, 1990
Summary
Three retinoic acid receptors (RARs) have distinct tissue expression patterns. The RAR beta gene is autoregulated by retinoic acid (RA), suggesting differential roles in RA physiology.
Area of Science:
- Molecular Biology
- Genetics
- Endocrinology
Background:
- Three retinoic acid receptors (RARs) are structurally homologous to steroid and thyroid hormone nuclear receptors.
- These receptors play crucial roles in cellular processes and development.
Purpose of the Study:
- To investigate the tissue distribution of RARs mRNA.
- To determine the autoregulation of the RAR beta gene by retinoic acid (RA).
- To elucidate the differential contribution of RARs to retinoic acid physiology.
Main Methods:
- Cloning of three retinoic acid receptors (RARs).
- Analysis of RARs mRNA tissue distribution using transcript analysis.
- Investigation of RAR beta gene autoregulation by RA.
Main Results:
- Distinct expression patterns were observed for RARs transcripts across different tissues.
- The RAR beta gene was found to be specifically autoregulated by RA.
- Evidence suggests differential roles for RARs in mediating retinoic acid's physiological effects.
Conclusions:
- The distinct tissue distribution and autoregulation of RAR beta indicate specialized functions for each RAR.
- These findings highlight the complex and differential roles of retinoic acid receptors in regulating physiological processes.