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The retinoic acid receptors
H de Thé1, P Tiollais, A Dejean
1Unité de Recombinaison et d'Expression Génétique (INSERM U163/CNRS UA 271), Institut Pasteur, Paris, France.
Nouvelle Revue Francaise D'Hematologie
|January 1, 1990
Abstract:
Three retinoic acid receptors (RAR), structurally homologous to steroid and thyroid hormone nuclear receptors, have recently been cloned. Analysis of the tissue distribution of RARs mRNAs have demonstrated a distinct expression pattern of the receptors' transcripts. Moreover, the RAR beta gene specifically, is autoregulated by RA. These findings suggest that the retinoic acid receptors differentially contribute retinoic acid physiology.