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Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
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Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...
Fatigue01:21

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Chronic Obstructive Pulmonary Disease01:24

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...

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Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
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Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

Chronic fatigue syndrome.

Steven Reid1, Trudie Chalder, Anthony Cleare

  • 1Imperial College, St Mary's Hospital, London, UK.

BMJ Clinical Evidence
|May 28, 2011
PubMed
Summary
This summary is machine-generated.

This systematic review examines treatments for Chronic Fatigue Syndrome (CFS), a condition affecting 0.006% to 3% of people. It evaluates the effectiveness and safety of various interventions for CFS patients.

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Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
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Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
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Published on: May 17, 2018

Area of Science:

  • Medical research
  • Systematic review
  • Evidence-based medicine

Background:

  • Chronic Fatigue Syndrome (CFS) impacts 0.006% to 3% of the population.
  • Women are disproportionately affected by CFS.
  • Prevalence varies based on diagnostic criteria.

Purpose of the Study:

  • To systematically review and evaluate treatments for Chronic Fatigue Syndrome (CFS).
  • To answer the clinical question regarding the effects of CFS interventions.
  • To assess the effectiveness and safety of various therapeutic options.

Main Methods:

  • Conducted a systematic literature review up to March 2010.
  • Searched major databases including Medline, Embase, and The Cochrane Library.
  • Included harms alerts from regulatory agencies like the FDA and MHRA.

Main Results:

  • Identified 46 relevant systematic reviews, RCTs, and observational studies.
  • Performed GRADE evaluations to assess the quality of evidence for interventions.
  • Synthesized data on the effectiveness and safety of numerous CFS treatments.

Conclusions:

  • Presents findings on interventions including antidepressants, CBT, and graded exercise therapy.
  • Evaluates the effectiveness and safety of dietary supplements, homeopathy, and immunotherapy.
  • Provides a comprehensive overview of available evidence for CFS treatments.