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Updated: Jun 1, 2026
18:48
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
Decrease of blood type antigenicity over the long-term after ABO-incompatible kidney transplantation.
Tatsu Tanabe1, Hideki Ishida, Shigeru Horita
1Department of Urology, Tokyo Women's Medical University, Japan.
Transplant Immunology
|May 28, 2011
Summary
In ABO-incompatible kidney transplants, donor blood-type antigens decrease over time, potentially aiding graft accommodation. Antigenic chimerism may indicate rejection in these long-term kidney transplant patients.
Area of Science:
- Immunology
- Transplantation Science
- Nephrology
Background:
- Limited research exists on changes in transplanted organ antigenicity post-transplantation.
- Understanding long-term antigenic shifts is crucial for improving transplant outcomes.
Purpose of the Study:
- To investigate long-term changes in blood-type antigen expression on kidney allografts after ABO-incompatible transplantation.
- To explore the relationship between antigen changes, accommodation, and rejection.
Main Methods:
- Immunohistochemical analysis of blood-type antigen expression in long-term ABO-incompatible kidney transplant recipients (n=6) and ABO-compatible controls (n=4).
- Assessment of antigen expression changes over time, including graft loss cases.
Main Results:
- ABO-incompatible grafts showed a gradual decrease in donor blood-type antigen expression over ten years (57.6%).
- One case of graft loss exhibited partial conversion of donor B to recipient A antigens, suggesting antigenic chimerism.
- No significant antigen changes were observed in ABO-compatible transplants (99.8% antigen-positive vessels >10 years).
Conclusions:
- Reduced donor antigen expression may contribute to long-term accommodation in ABO-incompatible kidney transplants.
- The development of antigenic chimerism on graft endothelium could signify an immunological response linked to antibody-mediated rejection.
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