Symptomatic hypoglycemia causing brain injury in a term breast fed newborn following early discharge

Ashish Marwah1, Geeta Gathwala

  • 1Neonatal services division, Department of Pediatrics, Pt. B.D. Sharma, PGIMS, Rohtak, Haryana, India. ashmar1980@gmail.com

Insights

Neonatal hypoglycemia, a condition of low blood glucose, can cause serious brain injury. Early discharge and feeding issues in newborns may increase the risk of this condition and its neurological complications.

Area of Science:

  • Neuroscience
  • Pediatrics
  • Endocrinology

Background:

  • Adequate blood glucose supply is crucial for cerebral metabolism and brain energy requirements.
  • Neonatal hypoglycemia is a known risk factor for acute and long-term neurological deficits.
  • Early hospital discharge without established feeding can exacerbate risks for newborns.

Observation:

  • A case study of a term newborn exclusively breastfed is presented.
  • The infant presented on the third day of life with symptomatic hypoglycemia.
  • Neurological injury was observed in conjunction with the hypoglycemia.

Findings:

  • Exclusively breastfed newborns can still develop symptomatic hypoglycemia.
  • Hypoglycemia in newborns can lead to significant neurological injury.
  • Feeding difficulties post-discharge may contribute to hypoglycemia.

Implications:

  • Highlights the importance of monitoring blood glucose in newborns, even those exclusively breastfed.
  • Emphasizes the need for adequate breastfeeding support before and after hospital discharge.
  • Underscores the potential for severe neurological complications from neonatal hypoglycemia.

Related Concept Videos

Hypoglycemia01:26

Hypoglycemia

Hypoglycemia is a blood glucose level below 70 mg/dL. It commonly occurs in individuals using insulin or insulin-secreting drugs, but may also arise in non-diabetic conditions. People with type 1 diabetes are at the highest risk because they depend on exogenous insulin. People with type 2 diabetes are also at risk, especially when treated with insulin or medications such as sulfonylureas, which increase insulin release regardless of blood glucose levels. It develops when insulin levels exceed...
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
Hyperglycemia01:29

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose levels exceed 180 mg/dL two...
Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes: