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Related Experiment Videos

CR2 complement receptor.

N R Cooper1, B M Bradt, J S Rhim

  • 1Department of Immunology, Research Institute of Scripps Clinic, La Jolla, California.

The Journal of Investigative Dermatology
|June 1, 1990
PubMed
Summary
This summary is machine-generated.

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Complement receptor 2 (CR2) binds complement fragments and Epstein-Barr virus on B lymphocytes. Research details CR2

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Complement receptor 2 (CR2) is a cell-surface glycoprotein found on B lymphocytes, follicular dendritic cells, and epithelial cells.
  • CR2 preferentially binds C3dg, a fragment of the third complement component, and also serves as a receptor for Epstein-Barr virus (EBV) on B lymphocytes.
  • Binding of C3dg to CR2 facilitates contact between complement activators and CR2-bearing cells, while EBV binding can lead to B cell infection.

Purpose of the Study:

  • To summarize the current understanding of the structure, genetics, and biological functions of CR2.
  • To detail the analysis of CR2's binding properties with its ligands.
  • To explore the structural correlates of CR2 functions using monoclonal antibodies.

Main Methods:

Related Experiment Videos

  • Purification of CR2 and analysis of its ligand-binding properties.
  • Development and application of monoclonal antibodies to study CR2 structure-function relationships.
  • Molecular cloning of CR2, deduction of its primary amino acid sequence, and expression in primate and rodent cells via cDNA transfection.
  • Analysis of soluble CR2 form, including its structure, electron microscopic appearance, and binding characteristics.

    • Main Results:

    • CR2 shares structural features with other complement and non-complement plasma and cell membrane proteins.
    • Genes encoding CR2 and related complement-associated proteins are located on chromosome 1 band q32.
    • Expressed CR2, in both cell-associated and soluble forms, retains its antigenic and functional integrity, allowing detailed structural and binding analysis.

    Conclusions:

    • CR2 plays a significant role in the complement system and B lymphocyte interactions.
    • The structural and genetic data provide insights into CR2's function and its relationship to other regulatory proteins.
    • Further research on CR2's structure and function can inform our understanding of immune responses and viral infections.