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Orthogonal projection approach applied to peak purity assessment
F C Sánchez1, J Toft, B van den Bogaert
1ChemoAC, Vrije Universiteit Brussel, Laarbeeklaan 103, B-1090 Brussels, Belgium.
Analytical Chemistry
|May 31, 2011
Abstract:
The orthogonal projection approach (OPA), a stepwise approach based on an orthogonalization algorithm, is proposed. The performance of OPA for the assessment of peak purity in HPLC-DAD is described and compared with that of SIMPLISMA. The occurrence of artifacts in both approaches under nonideal situations is discussed.
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