Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

MALDI-TOF Mass Spectrometry

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Serological profile of first SARS-CoV-2 reinfection cases detected within the SIREN study.

The Journal of infection·2021

Same author

Characterizing organic particle impacts on inert metal surfaces: Foundations for capturing organic molecules during hypervelocity transits of Enceladus plumes.

Meteoritics & planetary science·2020

Same author

Population-Level Antimicrobial Consumption Is Associated With Decreased Antimicrobial Susceptibility in Neisseria gonorrhoeae in 24 European Countries: An Ecological Analysis.

The Journal of infectious diseases·2019

Same author

Emerging cephalosporin and multidrug-resistant gonorrhoea in Europe.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2014

Same author

Beam deflection for temporal encoding in time-of-flight mass spectrometry.

Journal of the American Society for Mass Spectrometry·2013

Same author

Fast atom bombardment tandem mass spectrometry employing ion-molecule reactions for the differentiation of phospholipid classes.

Journal of the American Society for Mass Spectrometry·2013

Search research articles

Related Experiment Video

Updated: Jun 1, 2026

Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells

Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells

Published on: June 21, 2019

Valved sampling cell for membrane introduction mass spectrometry.

M A Lapack¹, J C Tou, M J Cole

¹Analytical Sciences Laboratory, The Dow Chemical Co., Midland, Michigan 48667.

Analytical Chemistry

|May 31, 2011

Summary

This study introduces a novel membrane extractor valve for mass spectrometry, demonstrating effective compound separation and controlled membrane permeability. Heating the interface tube minimizes adsorption, enhancing performance for polar compounds.

More Related Videos

Applications of the Single-probe: Mass Spectrometry Imaging and Single Cell Analysis under Ambient Conditions

Applications of the Single-probe: Mass Spectrometry Imaging and Single Cell Analysis under Ambient Conditions

Published on: June 14, 2016

Sample Preparation for Single Cell Mass Spectrometry Metabolomics Studies: Combined Cell Washing, Quenching, Drying, and Storage

Sample Preparation for Single Cell Mass Spectrometry Metabolomics Studies: Combined Cell Washing, Quenching, Drying, and Storage

Published on: September 16, 2025

Related Experiment Videos

Last Updated: Jun 1, 2026

Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells

Integrated Cell Manipulation Platform Coupled with the Single-probe for Mass Spectrometry Analysis of Drugs and Metabolites in Single Suspension Cells

Published on: June 21, 2019

Applications of the Single-probe: Mass Spectrometry Imaging and Single Cell Analysis under Ambient Conditions

Applications of the Single-probe: Mass Spectrometry Imaging and Single Cell Analysis under Ambient Conditions

Published on: June 14, 2016

Sample Preparation for Single Cell Mass Spectrometry Metabolomics Studies: Combined Cell Washing, Quenching, Drying, and Storage

Sample Preparation for Single Cell Mass Spectrometry Metabolomics Studies: Combined Cell Washing, Quenching, Drying, and Storage

Published on: September 16, 2025

Area of Science:

Analytical Chemistry
Mass Spectrometry Instrumentation

Background:

Membrane extractors integrated into valves enable compound separation and direct introduction into mass spectrometers.
Control over membrane parameters like temperature is crucial for optimal performance and preventing damage.

Purpose of the Study:

To evaluate the performance of a novel membrane extractor valve system for mass spectrometry.
To investigate the impact of valve-to-spectrometer distance and interface tube length on response and response times.

Main Methods:

The membrane extractor valve was tested with varying interface tube lengths between the valve and the mass spectrometer.
Steady-state response measurements were recorded at different distances from the ion source.
Response times for polar compounds were analyzed in relation to interface tube length.

Main Results:

Steady-state response measurements showed no significant variation with valve distance from the ion source.
Polar compounds exhibited a notable dependency of response time on interface tube length.
Heating the interface tube effectively minimized adsorption phenomena.

Conclusions:

The developed membrane extractor valve offers controlled experimental parameters for mass spectrometry applications.
Interface tube heating is a key strategy to mitigate adsorption issues, particularly for polar analytes.
The system demonstrates robust performance with potential for optimized sample introduction.