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Reference intervals of serum lipid profile in healthy Indian school children and adolescents

R K Marwaha1, R Khadgawat, N Tandon

  • 1Dept of Endocrinology & Thyroid Research, Institute of Nuclear Medicine and Allied Sciences, Delhi, India. marwaha_ramank@hotmail.com

Clinical Biochemistry
|May 31, 2011
PubMed

Insights

This study establishes crucial age and sex-specific reference intervals for serum lipid parameters in healthy Indian children aged 6-17 years. These findings aid in assessing lipid health and identifying potential risks in pediatric populations.

Area of Science:

  • Pediatric Endocrinology
  • Clinical Biochemistry
  • Public Health Nutrition

Background:

  • Establishing accurate reference intervals for serum lipid parameters is vital for pediatric health assessment.
  • Previous data for Indian children is limited, necessitating region-specific studies.
  • Understanding lipid profiles in children is key to early cardiovascular risk detection.

Purpose of the Study:

  • To determine age- and sex-specific reference intervals for serum lipid parameters.
  • To provide a benchmark for evaluating lipid health in Indian children.
  • To facilitate early identification of dyslipidemia in the pediatric population.

Main Methods:

  • A cross-sectional study involving 3076 healthy Indian children aged 6-17 years from Delhi.
  • Exclusion of children with overweight or obesity based on Body Mass Index (BMI).
  • Statistical analysis to derive mean, standard deviation, and centile values for lipid parameters.

Main Results:

  • Serum lipid parameters (total cholesterol, triglycerides, HDL, LDL) showed significant differences between sexes, with higher levels in girls.
  • Approximately 89.2% of subjects had acceptable total cholesterol levels.
  • Optimal serum triglyceride levels were observed in 45.1%, while only 0.3% had optimal HDL cholesterol.

Conclusions:

  • Age- and sex-specific reference intervals for serum lipid parameters in healthy Indian children (6-17 years) have been established.
  • These reference intervals serve as a critical tool for clinical interpretation of lipid profiles in this demographic.
  • The data highlights potential areas for public health interventions regarding lipid management in Indian children.
Abstract

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