Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
Structure of Blood Vessels01:15

Structure of Blood Vessels

Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...
Overview of the Vascular System01:20

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Cell Motility through Blebbing01:16

Cell Motility through Blebbing

Blebs are a type of membrane protrusion formed by the internal hydrostatic pressure of the cytoplasm. Blebs are observed in several cell types, including fibroblasts, immune cells, and single-celled organisms like the amoeba. The primary function of blebs is cell locomotion and apoptosis, but they are also found during necrosis and cell division. The life cycle of a bleb comprises an initiation phase followed by the expansion and retraction phases.
Blebbing Through the Matrix
In multicellular...
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perivascular Adipose Tissue Anticontractile Function Is Mediated by Both Endothelial and Neuronal Nitric Oxide Synthase Isoforms.

Journal of vascular research·2022
Same author

Restoring Perivascular Adipose Tissue Function in Obesity Using Exercise.

Cardiovascular drugs and therapy·2021
Same author

Interleukin-33 rescues perivascular adipose tissue anticontractile function in obesity.

American journal of physiology. Heart and circulatory physiology·2020
Same author

MiRNAs as Novel Adipokines: Obesity-Related Circulating MiRNAs Influence Chemosensitivity in Cancer Patients.

Non-coding RNA·2020
Same author

Perivascular Adipose Tissue Contributes to the Modulation of Vascular Tone in vivo.

Journal of vascular research·2019
Same author

Mechanistic Links Between Obesity, Diabetes, and Blood Pressure: Role of Perivascular Adipose Tissue.

Physiological reviews·2019
Same journal

Compositional and Functional Metabolic Shifts in the Endometrial Microbiota of Cows (<i>Bos taurus</i>) During the Transition Period: A Metagenomic Next-Generation Sequencing Approach.

Frontiers in bioscience (Elite edition)·2026
Same journal

Insights Into the Characterization and Application of <i>Pseudomonas taetrolens</i>.

Frontiers in bioscience (Elite edition)·2026
Same journal

Small Helper Ti-plasmid Coexisting With the <i>A281virF</i> Gene Encoding an F-Box-Like Protein Improves the Efficiency of T-DNA Transfer From <i>Agrobacterium</i> Cells to Plant Cells.

Frontiers in bioscience (Elite edition)·2026
Same journal

AAV9-Mediated Targeting of Defined Neuronal Populations in Spinal Cord Through Intrathecal Injection.

Frontiers in bioscience (Elite edition)·2026
Same journal

Progress in Bioengineering: An Extensive Examination of State-of-the-Art Innovations in the Development of Artificial Corneas.

Frontiers in bioscience (Elite edition)·2026
Same journal

Nitrosylcobalamin Selectively Targets Tumors via Cobalamin Uptake and Lysosomal Processing.

Frontiers in bioscience (Elite edition)·2026
See all related articles

Related Experiment Video

Updated: Jun 1, 2026

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro
08:28

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro

Published on: February 15, 2022

C-Myb function in the vessel wall.

Kelly A Farrell1, Sarah B Withers, Cathy M Holt

  • 1Core Technology Facility, University of Manchester, Manchester, UK.

Frontiers in Bioscience (Elite Edition)
|May 31, 2011
PubMed
Summary
This summary is machine-generated.

C-Myb, a transcription factor, plays a key role in vascular smooth muscle cell (VSMC) proliferation and apoptosis. Targeting c-Myb may offer new treatments for vasculoproliferative diseases.

More Related Videos

A Method for Labeling Vasculature in Embryonic Mice
09:58

A Method for Labeling Vasculature in Embryonic Mice

Published on: October 7, 2011

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta
10:57

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta

Published on: September 12, 2017

Related Experiment Videos

Last Updated: Jun 1, 2026

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro
08:28

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro

Published on: February 15, 2022

A Method for Labeling Vasculature in Embryonic Mice
09:58

A Method for Labeling Vasculature in Embryonic Mice

Published on: October 7, 2011

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta
10:57

Using In Vivo and Tissue and Cell Explant Approaches to Study the Morphogenesis and Pathogenesis of the Embryonic and Perinatal Aorta

Published on: September 12, 2017

Area of Science:

  • Cardiovascular Biology
  • Molecular Biology
  • Cellular Biology

Background:

  • C-Myb is a DNA-binding transcription factor regulating apoptosis, proliferation, and differentiation.
  • Previous studies show c-Myb knockdown reduces vascular smooth muscle cell (VSMC) proliferation and increases apoptosis.
  • Reduced c-Myb activity decreases neointimal formation by inhibiting VSMC proliferation.

Purpose of the Study:

  • To review the function of c-Myb in vascular biology.
  • To explore signaling interactions of c-Myb.
  • To evaluate c-Myb as a potential therapeutic target for vasculoproliferative diseases.

Main Methods:

  • Literature review of in vitro and in vivo studies on c-Myb in vascular injury.
  • Analysis of studies investigating c-Myb's role in VSMC proliferation, apoptosis, and neointimal formation.
  • Examination of signaling pathways involving c-Myb.

Main Results:

  • C-Myb knockdown in VSMCs reduces proliferation and increases apoptosis.
  • Reduced c-Myb activity inhibits neointimal hyperplasia in vivo.
  • Overexpression of c-Myb can increase survival in specific cell types.

Conclusions:

  • C-Myb is a critical regulator of VSMC behavior in vascular injury.
  • Modulating c-Myb activity presents a potential therapeutic strategy for vasculoproliferative disorders.
  • Further research into c-Myb signaling interactions is warranted for targeted therapies.